Graphene-based wearable biosensors for point-of-care diagnostics: From surface functionalization to biomarker
Jiawen Song1, Yang Luo2, Zhuang Hao1
1School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
Graphene wearable biosensors offer non-invasive, real-time health monitoring for point-of-care diagnostics. Surface functionalization is key to enhancing sensitivity and selectivity for biomarker detection in personalized medicine.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Growing demand for non-invasive, real-time health monitoring.
- Development of graphene-based wearable biosensors for point-of-care (POC) diagnostics.
- Graphene's unique electrical, mechanical, and biocompatible properties.
Purpose of the Study:
- Review surface functionalization of graphene for wearable biosensors.
- Enhance performance of biosensors for biomarker detection.
- Explore integration into POC devices for personalized medicine.
Main Methods:
- Discuss covalent and non-covalent functionalization strategies.
- Analyze biomolecular probes and passivation layers for sensor performance.
- Categorize biomarkers and review wearable designs (patches, lenses, textiles).
Main Results:
- Surface functionalization significantly improves sensitivity and selectivity for biomarker detection.
- Various wearable designs demonstrate integration potential for POC applications.
- Graphene biosensors show promise for revolutionizing personalized medicine.
Conclusions:
- Surface functionalization is critical for advanced graphene wearable biosensors.
- Challenges and opportunities exist in translating lab-based sensors to real-world applications.
- Graphene biosensors represent a roadmap for next-generation diagnostics and personalized healthcare.
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