Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inclusive Fitness

Inclusive Fitness

Most altruistic behavior—in which one animal helps another at a cost to themselves—occurs between relatives. Scientists think these altruistic behaviors evolved because they increase the inclusive fitness of the animal providing help.

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Eye metrics often reflect visual conscious awareness, conscious content, and neural processing in cerebral blindness.

Communications biology·2025

Same author

Orientation Maps in Mouse Superior Colliculus Explained by Population Model of Non-Orientation Selective Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same author

Limitations of 2-dimensional line-scan MRI for directly measuring neural activity.

Imaging neuroscience (Cambridge, Mass.)·2025

Same author

Principles of intensive human neuroimaging.

Trends in neurosciences·2024

Same author

Plaudits for logits in sensory neuroscience.

Neuron·2024

Same author

Efficient coding of natural images in the mouse visual cortex.

Nature communications·2024

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

Shared computational principles for mouse superior colliculus and primate population orientation selectivity.

Austin Kuo^1,2,3, Justin L Gardner^4,3, Elisha P Merriam¹

¹Laboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD.

Biorxiv : the Preprint Server for Biology

|June 26, 2025

Summary

This summary is machine-generated.

Computational models reconcile orientation selectivity differences between mouse and primate visual systems. This research suggests shared principles in neural processing, enabling cross-species generalization of findings.

More Related Videos

Extracellular Recording of Neuronal Activity Combined with Microiontophoretic Application of Neuroactive Substances in Awake Mice

Extracellular Recording of Neuronal Activity Combined with Microiontophoretic Application of Neuroactive Substances in Awake Mice

Published on: May 21, 2016

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Published on: April 21, 2023

Related Experiment Videos

Last Updated: Jun 28, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

Extracellular Recording of Neuronal Activity Combined with Microiontophoretic Application of Neuroactive Substances in Awake Mice

Extracellular Recording of Neuronal Activity Combined with Microiontophoretic Application of Neuroactive Substances in Awake Mice

Published on: May 21, 2016

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

Published on: April 21, 2023

Area of Science:

Neuroscience
Computational Neuroscience
Visual System Research

Background:

Mouse and primate visual systems exhibit differences, particularly in orientation selectivity within the superior colliculus (SC).
Primate SC typically lacks orientation selectivity, unlike mouse superficial SC, raising questions about conserved computational principles.

Purpose of the Study:

To reconcile observed differences in orientation selectivity between mouse and primate visual systems.
To investigate if conserved computational principles underlie orientation selectivity despite species-specific variations.

Main Methods:

Developed computational models of mouse superficial SC populations using fixed, stimulus-invariant receptive fields (RFs).
Simulated neural responses at varying spatial frequencies to assess orientation selectivity.
Visualized stimulus-RF interactions in the spatial frequency domain.

Main Results:

Model RFs demonstrated orientation selectivity that varied with spatial frequency, matching experimental calcium imaging data.
Stimulus-invariant RFs, common in primate lateral geniculate nucleus (LGN) and V1, explained much of the mouse SC data.
Reversed orientation selectivity was observed at non-preferred spatial frequencies.

Conclusions:

A parsimonious population modeling approach explains stimulus-dependent orientation selectivity in mouse superficial SC.
Intrinsic orientation selectivity in individual cells is not required to explain population-level data.
The study provides a framework for identifying shared computational principles across species' visual systems.