Responsiveness of ventrobasal thalamic neurons after suppression of S1 cortex in the anesthetized rat

Corticofugal influences on the responses of ventrobasal (VB) thalamic neurons to repetitive stimuli were studied in anesthetized rats by suppressing primary somatosensory (S1) electrocortical activity with topically applied lidocaine. Effective concentrations of lidocaine were confined to S1 and immediately adjacent cortex and suppressed evoked S1 responses and corticofugal discharges. Suppression of S1 cortex reduced the average number of spikes discharged by 83 VB neurons in response to each of 25 electrical somatic stimuli delivered at frequencies ranging from 1 to 50 Hz. Of 20 units studied both before and after S1 suppression, 14 (70%) showed a similar reduced response to repetitive stimuli. Cortical suppression produced no consistent changes in spontaneous activity, somatic stimulus threshold, response latency, or size of receptive field. There was no significant difference in the effect of cortical suppression on the responsiveness of 8 VB neurons to repetitive medial lemniscal, as compared to somatic, stimuli. We conclude that, in the anesthetized rat, S1 corticofugal activity facilitates somato-sensory transmission to VB neurons and that this facilitation is mediated, at least in part, by corticothalamic neurons.