Psoriasis: an update on topical and systemic therapies

Area of Science:

• Immunodermatology
• Systemic Inflammatory Diseases
• Genetics

Background:

• Psoriasis is an immune-mediated inflammatory disease with genetic links.
• It primarily affects the skin but is systemic, linked to comorbidities like arthritis, cardiovascular disease, and depression.
• Patient education on chronicity and comorbidities is crucial for management.

Purpose of the Study:

• To outline the management of psoriasis, from topical therapies to advanced systemic treatments.
• To highlight the role of newer therapies in addressing the systemic nature of psoriasis.
• To emphasize the potential for significant symptom resolution with advanced treatments.

Main Methods:

• Review of current psoriasis management strategies.
• Discussion of treatment escalation based on disease severity and patient symptoms.
• Overview of traditional systemic therapies (methotrexate) and phototherapy.
• Introduction to newer targeted therapies, including oral and biologic agents.

Main Results:

• Topical therapies are suitable for limited, non-systemic psoriasis.
• Phototherapy and traditional systemic agents like methotrexate are used for more extensive disease.
• Biologic and oral therapies are reserved for cases unresponsive to traditional treatments.
• Biologic therapies demonstrate potential for near-complete symptom resolution.

Conclusions:

• Psoriasis management requires a tailored approach based on disease extent and systemic involvement.
• Advanced therapies, particularly biologics, offer effective options for severe or refractory psoriasis.
• Understanding psoriasis as a chronic, systemic condition with comorbidities is key to optimal patient care.