Related Experiment Video
Updated: Sep 18, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Electrochemically driven direct C-H difluoroethylation of (hetero)arenes under metal/catalyst-free conditions
Luping Zheng1,2, Yunfei Tian1, Zhihui Gao1
1College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, Henan 471934, P. R. China. tianyunfly1120@163.com.
Abstract:
An efficient electrochemical method for the regioselective difluoroethylation of various (hetero)arenes was smoothly accomplished. Without metal catalysts and external oxidants involved, this method leads to the easy accessibility of valuable CF2Me-substituted architectures. Notably, this electrochemical protocol successfully enabled the other valuable fluoroalkylation of heteroarenes. The controlled experiments indicated that a radical mechanism was involved in this transformation. The mild reaction conditions, excellent functional group compatibility, and good efficiency and selectivity render this method a promising strategy for late-stage modification of bioactive complex molecules.
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Electrophilic Aromatic Substitution: Friedel–Crafts Alkylation of Benzene
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Electrophilic Aromatic Substitution: Friedel–Crafts Acylation of Benzene
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
