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Updated: Sep 18, 2025

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
Published on: June 3, 2014
Splay and bend deformations in cells near corners
Aniruddh Murali1, Prasoon Awasthi1, Kirsten Endresen2
1Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense, Denmark. serra@sdu.dk.
None:
The study of spindle-like cells as nematic liquid crystals has led to remarkable insights in the understanding of tissue organization and morphogenesis. In the characterization of this anomalous liquid crystal material, we focus on the energetic cost of splay and bend deformations, in order to determine the elastic anisotropy of the material, i.e. the ratio of the elastic constants associated with splay and bend. We explore the behavior of monolayers of cells in proximity to corners, where cells arrange in splay or bend configuration, depending on the amplitude of the wedge angle. The angle at which splay and bend deformations are equally likely is determined by the ratio between splay and bend elastic constants. Our data suggest that for fibroblast cells the common approximation of bend and splay constants being equal is valid.
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