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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Cisapride for gastric emptying in diabetic patients: a meta-analysis on its efficacy and safety
Yifan Lu1,2,3, Yixuan Xie2,3, Xinyi Yang2,3
1State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People's Republic of China.
Background:
Diabetic gastroparesis is a common complication of diabetes, characterized by delayed gastric emptying, significantly impacting patients' quality of life. Current treatment options are limited often resulting in unsatisfactory outcomes. This meta-analysis aims to evaluate the efficacy and safety of cisapride in diabetic patients suffering from gastroparesis.
Methods:
A systematic literature search identified 13 studies involving 185 participants. Data on gastric emptying rates, symptom relief, and safety profiles were extracted and analyzed. Effectiveness was measured through gastric emptying half-life (T1/2, measured in min), 120-min gastric emptying rate (measured as a percentage), and adverse events.
Key Results:
The analysis revealed that cisapride significantly improved gastric emptying compared to placebo, with a mean difference (MD) of -33.74 for T1/2 (95% CI: -68.84 to -2.65, P = 0.03). Additionally, the 120-min gastric emptying rate improved by -25.84 (95% CI: -16.80 to -25.84, P < 0.001). The occurrence of adverse events was low, with most patients tolerating the treatment well.
Conclusion And Inferences:
Cisapride demonstrates notable efficacy in improving gastric emptying in diabetic gastroparesis, with a generally acceptable safety profile. Clinicians should consider cisapride as a viable treatment option while monitoring patients for any potential side effects. Further research is warranted to explore long-term safety and effectiveness.
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