Related Experiment Video
Updated: Sep 18, 2025
23:56
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
16.8K
How plausible is it that PEP would be cost-effective in sub-Saharan Africa?
Geoffrey Peter Garnett1, Peter Godfrey-Faussett2
1TB & HIV Team, Gates Foundation, Seattle, Washington, USA.
Journal of the International AIDS Society
|June 26, 2025
Summary
Post-exposure prophylaxis (PEP) is effective for HIV prevention, especially for single encounters or early in partnerships. Its cost-effectiveness hinges on HIV prevalence, transmission rates, and PEP efficacy, with cost-savings in high-prevalence, low-treatment settings.
Area of Science:
- Public Health
- Epidemiology
- Health Economics
Background:
- Post-exposure prophylaxis (PEP) is a proven HIV prevention method when administered promptly after potential exposure.
- Understanding the economic viability of PEP is crucial for informing local HIV prevention policies.
Purpose of the Study:
- To analyze the cost-effectiveness of PEP across various epidemiological and healthcare contexts.
- To identify key factors influencing PEP's economic value in HIV prevention strategies.
Main Methods:
- Utilized mathematical modeling to assess PEP cost-effectiveness.
- Incorporated variables such as HIV prevalence, transmission probability per sexual act, PEP efficacy, and associated costs.
Main Results:
- PEP is cost-saving in settings with high HIV prevalence and low antiretroviral therapy (ART) coverage.
- Cost-effectiveness is maintained at HIV prevalences above 15% with 90:90:90 ART coverage targets.
- PEP is unlikely to be cost-effective at 95:95:95 ART coverage levels.
- The cost-effectiveness is highly sensitive to factors like the proportion of individuals with unsuppressed HIV, transmission dynamics, and PEP costs.
Conclusions:
- Simple calculations can define PEP cost-effectiveness.
- PEP is most cost-effective for one-off sexual encounters or the initial acts within a partnership, particularly in high HIV prevalence areas.
- Local data are essential for accurate PEP cost-effectiveness evaluations.
Related Concept Videos
01:22Dose-Response Relationship: Potency and Efficacy
5.3K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
5.3K
01:26Methods Of Healthcare Delivery System
3.5K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.5K