Arp2/3-complex regulation - Novel insights and open questions
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Updated: Sep 18, 2025

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
Published on: May 19, 2016
Theresia E B Stradal1, Micaela Boiero Sanders2, Peter Bieling3
1Department of Cell Biology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Abstract:
Arp2/3 complex is a central actin filament generator driving numerous motile processes in cells. It was originally isolated from Acanthamoeba approx. 30 years ago. It is highly conserved throughout eukaryotic life and composed of 7 subunits, two of which are actin related proteins, ARP2 and ARP3. Since then the modalities of its regulation were continuously unraveled, bringing about a large number of proteins that affect its activity. We here set out to briefly review our current knowledge and identify open questions that demand answers and add new twists, advancing our understanding to reflect physiological complexity.
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