Cancer-affected tissue regeneration employing cisplatin-loaded polymeric nanoplatforms

Initially referred to as Peyrone's salt, named after its developer Michele Peyrone, it was Barnett Rosenberg's serendipitous discovery of cisplatin's inhibitory effects on cellular division that garnered significant attention. The subsequent promising results in the treatment of several cancer types resulted in its authorization for cancer therapy. Subsequently, researchers have created many analogues of cisplatin. Although cisplatin plays a crucial role in cancer therapy, its use is hindered mostly by medication toxicity and resistance. Consequently, strategies such as combination treatment and the use of nanoplatforms have arisen to enhance therapeutic effectiveness. Recently, there has been a surge in the usage of nanoplatforms for targeted drug delivery to cure illnesses and promote tissue regeneration. The significance of cisplatin in cancer therapy has prompted much research on its delivery to tumor locations using different nanoplatforms. The positive results in lowering cisplatin's systemic toxicity, improving its pharmacokinetics and bioavailability, and helping damaged tissues heal have made it much more likely that these drug delivery methods will be widely used. Nonetheless, many problems have arisen in the development of suitable delivery strategies for cisplatin. The purpose of this work is to present a thorough narrative analysis of several nanoplatforms and related methods for cisplatin encapsulation, including their advantages and disadvantages, biological and physical effects and characteristics, as well as their applications, while also considering future perspectives and research, all with the objective of enhancing the efficacy of cancer therapies and tissue regeneration while minimizing adverse effects.