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Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

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Related Experiment Video

Updated: Sep 18, 2025

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

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In-office Bleaching After a Desensitizing Protocol: a 4.5-Year Follow-up of a Randomized Controlled Trial.

Diego Hortkoff¹, Paulo Vitor Farago², João Carlos Gomes¹

¹Department of Dentistry, State University of Ponta Grossa - UEPG, Ponta Grossa, Paraná, Brazil.

Journal of Dentistry

|June 26, 2025

Summary

In-office dental bleaching provides sustained whitening for over 4.5 years. Desensitization did not significantly impact long-term color change, though some color rebound occurred.

Keywords:

Arginine Dental Esthetic Hydrogen Peroxide Ibuprofen Tooth Sensitivity Tooth bleaching

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Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites

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Published on: November 9, 2014

Area of Science:

Dentistry
Aesthetic Dentistry
Dental Materials

Background:

In-office dental bleaching is a popular aesthetic procedure.
Assessing the long-term efficacy and patient experience is crucial.

Purpose of the Study:

To evaluate the 4.5-year bleaching efficacy and longevity of in-office dental bleaching.
To determine the effect of ibuprofen/arginine desensitization on bleaching outcomes and patient sensitivity.

Main Methods:

A randomized clinical trial involving 62 patients with darker canines.
In-office bleaching with 35% hydrogen peroxide, with or without desensitizing gel.
Color change assessment using Vita Classical, Vita Bleachedguide, and spectrophotometry at baseline, 1 month, and 4.5 years.

Main Results:

No significant difference in color change between desensitizing and placebo groups after 4.5 years.
Clinically relevant whitening persisted, with a mean color rebound of 2.1 ΔSGU units.
25.5% reported long-term tooth sensitivity; patient satisfaction was moderate (VAS 6.7), with 85.1% desiring further bleaching.

Conclusions:

In-office dental bleaching offers sustained whitening effects over 4.5 years.
Ibuprofen/arginine desensitization did not significantly alter long-term bleaching efficacy.
Despite mild color rebound, results indicate clinically acceptable whitening longevity.