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Updated: Sep 18, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Light/Copper(I) Synergistically Catalyzes the Three-Component Radical Monofluoroalkyl Arylation of Styrenes
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
Abstract:
A three-component radical monofluoroalkyl arylation reaction of styrenes with ethyl bromofluoroacetate and (hetero)arenes catalyzed by light/copper(I) synergy is established herein. In a one-step reaction, two new C-C bonds and 1,1-di(hetero)aryl skeletons can be constructed. This reaction has the characteristics of mild reaction conditions, good yields, a wide range of substrates, and good regioselectivity. In addition, this method is suitable for the construction and large-scale synthesis of complex molecules, providing a new avenue for the late monofluorination modification of natural products and drugs.
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