Related Experiment Video
Updated: May 8, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
Oxidative stress, burnout, National Institutes of Health, work relative value units, and Medicaid: Need for an
Satyan Lakshminrusimha1, Timothy E Albertson2, Susan Murin2,3
1Division of Neonatology, Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, USA. slakshmi@ucdavis.edu.
Abstract:
There are several similarities between oxygen transport and medical economics. In a critically ill, anemic patient, increasing inspired oxygen is not an effective strategy to improve tissue oxygen delivery. A transfusion of packed red cells to increase hemoglobin increases arterial oxygen content and delivery to the tissues. Similarly, low reimbursement by Medicaid and reduced funding from National Institutes of Health (NIH) and National Science Foundation (NSF) cannot be compensated by increased provider work hours. Increased federal funding of Centers for Medicare and Medicaid Services (CMS), NIH and NSF are needed to sustain pediatric clinical and research workforce. IMPACT: Reduction in funding to Medicaid, NIH and NSF will impact pediatric clinical care and research. Increased work hours to compensate for low Medicaid, NIH and NSF funding can lead to burnout and stress. There are similarities between oxidative stress related to high FiO2 and burnout related to high FTE (full-time equivalent) work hours. Providing a blood transfusion increases arterial oxygen content and delivery to tissues. Supporting Medicaid, NIH and NSF will enhance pediatric clinical care and research.
Related Concept Videos
Ethical Issues
Ethical Concerns in Healthcare:
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Acute Coronary Syndrome IV: Interprofessional Care
Heart Failure VI: Adjunct Therapies

