Sex effects on dynamic structure-function coupling of intrinsic brain network
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View abstract on PubMed
Summary
This summary is machine-generated.This study reveals sex differences in dynamic brain connectivity. Females show stronger structure-function coupling in certain brain states, impacting cognitive performance.
Area Of Science
- Neuroscience
- Brain Connectivity
- Sex Differences in Brain Function
Background
- Static structure-function coupling (SC-FC) differences between sexes are known.
- The dynamic nature of the human brain's neural activity is not captured by static models.
- Understanding sex influences on time-varying SC-FC coupling is crucial for brain organization insights.
Purpose Of The Study
- To investigate sex differences in dynamic functional connectivity (FC) strength and SC-FC coupling.
- To analyze these differences at the level of intrinsic functional networks.
- To explore the relationship between dynamic SC-FC coupling and cognitive performance across sexes.
Main Methods
- Utilized a sliding window approach to construct dynamic FC networks.
- Employed k-means clustering to identify hyper-connected and hypo-connected brain states.
- Analyzed SC-FC coupling using two window sizes (50 TRs and 30 TRs).
Main Results
- Females exhibited higher whole-brain SC-FC coupling in the hyper-connected state, particularly in default mode network systems.
- Females also showed higher FC strength and coupling in limbic/paralimbic and subcortical networks during the hypo-connected state.
- Males displayed greater FC strength and coupling in somatosensory/motor and auditory networks in the hyper-connected state.
Conclusions
- Significant sex-specific patterns exist in dynamic SC-FC coupling across different brain states.
- These patterns are correlated with cognitive performance, suggesting a neurodevelopmental basis for cognitive function.
- This research offers novel insights into sex-related effects on brain dynamics and cognition.
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