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Related Experiment Videos

Pathologic involvement of the urinary bladder in progressive systemic sclerosis.

E V Lally, S R Kaplan, J G Susset

    The Journal of Rheumatology
    |August 1, 1985
    PubMed
    Summary

    Progressive systemic sclerosis (PSS) can cause urinary bladder abnormalities, including increased connective tissue and vascular changes. These findings may explain urinary symptoms and hematuria in PSS patients.

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    Area of Science:

    • Urology
    • Rheumatology
    • Pathology

    Background:

    • Progressive systemic sclerosis (PSS) is a multisystem autoimmune disease.
    • Urinary tract involvement in PSS is recognized but bladder-specific pathology is less understood.

    Observation:

    • Two patients with PSS presented with urinary symptoms and microscopic hematuria.
    • Pathologic examination of bladder tissue revealed characteristic abnormalities.

    Findings:

    • Both patients showed increased connective tissue deposition in the bladder's lamina propria and smooth muscle layers.
    • One patient exhibited endovascular proliferation in small bladder arteries.
    • Clinical manifestations included persistent microscopic hematuria, urinary frequency, and incontinence.

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    Implications:

    • Structural or functional bladder abnormalities may be a manifestation of PSS.
    • These pathological findings may contribute to the urinary symptoms observed in PSS patients.
    • Further research is needed to clarify the direct relationship between PSS and bladder pathology.