Healthcare-Associated Clostridioides difficile Infection: A Hospital-Based Retrospective Study in North Eastern...

Area of Science:

• Infectious Diseases
• Epidemiology
• Clinical Medicine

Background:

• Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired diarrhea with increasing incidence and severity.
• CDI presents a significant global health burden, affecting morbidity, mortality, and healthcare expenditures.

Purpose of the Study:

• To evaluate clinical and laboratory features of CDI patients.
• To assess treatment strategies and their impact on patient outcomes.
• To identify risk factors associated with CDI recurrence and mortality.

Main Methods:

• Retrospective cohort study conducted over 30 months.
• Inclusion of 534 patients diagnosed with CDI.
• Analysis of clinical data, laboratory results, and patient outcomes.

Main Results:

• Fever and age over 65 were linked to longer hospital stays.
• Co-infection with A/B toxins and GDH, and obesity were significant predictors of CDI recurrence.
• Female patients over 65 faced a survival probability below 60% after 21 days.

Conclusions:

• Comprehensive risk assessment, focusing on age and comorbidities, is vital for effective CDI management.
• Timely therapeutic interventions can improve outcomes in high-risk CDI populations.
• Understanding specific risk factors aids in optimizing patient care pathways for CDI.