Graphene Quantum Dots for Glioblastoma Treatment and Detection-Systematic Review

Area of Science:

• Nanotechnology
• Oncology
• Biomedical Engineering

Background:

• Glioblastoma presents a significant therapeutic challenge due to its aggressive nature and poor patient prognosis.
• Existing treatments for glioblastoma have limited efficacy, driving the need for novel therapeutic strategies.
• Graphene quantum dots (GQDs) possess unique properties, including biocompatibility and blood-brain barrier permeability, making them attractive for biomedical applications.

Purpose of the Study:

• To systematically review the current applications of graphene quantum dots (GQDs) in the management of glioblastoma.
• To evaluate the potential of GQDs as multifunctional platforms for glioblastoma therapy.

Main Methods:

• A comprehensive literature search was conducted across major scientific databases (PubMed, Science Direct, Web of Science).
• 658 relevant papers were identified, and 10 studies meeting specific eligibility criteria were selected for this systematic review.
• The selected studies were analyzed to identify the applications of GQDs in glioblastoma research.

Main Results:

• The majority of reviewed studies utilized GQDs as pretreatment agents for chemotherapy and photothermal therapy.
• GQDs demonstrated utility in biosensing, bioimaging, and targeted drug delivery systems for glioblastoma.
• Research indicates GQDs can enhance therapeutic efficacy and diagnostic capabilities in glioblastoma models.

Conclusions:

• Graphene quantum dots represent a promising multifunctional platform for advancing glioblastoma treatment strategies.
• Despite current research limitations, GQDs hold significant potential for improving therapeutic precision and reducing side effects.
• Further optimization and clinical studies are crucial to translate GQD-based therapies into effective glioblastoma treatments.