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Updated: Sep 18, 2025

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Structural Aspects of Arylpiperazines as Aminergic GPCR Ligands

Agata Bartyzel1, Beata Cristóvão1, Agnieszka A Kaczor2,3

  • 1Department of General and Coordination Chemistry and Crystallography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Maria Curie-Sklodowska Sq. 2, 20-031 Lublin, Poland.

Molecules (Basel, Switzerland)
|June 27, 2025
PubMed
Summary

Arylpiperazines are versatile compounds used in drug discovery for CNS disorders and cancer. This review details their structures and interactions with aminergic G protein-coupled receptors (GPCRs).

Keywords:
CNS disordersGPCRsX-ray structurearylpiperazinesmolecular modelingpharmacophore modelsstructure–activity relationship

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