Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-Specific Relationships between Cerebral Cortex Metabolism, Behavior, and ECG Parameters in Rats under Physiological Conditions and after Pyruvate Dehydrogenase Inhibition.

Biochemistry. Biokhimiia·2026
Same author

Polycationic Biocidal Coatings: The Mechanism of Their Interaction with Cells.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Changes in Mechanical Properties and Structure of PET Films Treated with Metagenome-Derived LCC<sup>ICCG</sup> PETase Heterologously Expressed in <i>Penicillium verruculosum</i>.

Polymers·2026
Same author

Chemodivergent Approach to 1,2,3-Triazole-Fused Quinazolines.

The Journal of organic chemistry·2026
Same author

Divergent assembly of fused polycyclic scaffolds from iodotriazole-tethered benzaldehydes.

Organic & biomolecular chemistry·2026
Same author

Microbial Synthesis and Biological Activity of 20β-Hydroxylated Progestins: Ovarian and Neural Action of 17α,20β,21α-Trihydroxy-4-Pregnen-3-One in <i>Danio rerio</i>.

Biomolecules·2026

Related Experiment Video

Updated: May 10, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

24.2K

pH-Sensitive Multiliposomal Containers for Encapsulation and Rapid Release of Bioactive Substances.

Anna A Efimova1, Tatyana A Abramova1, Igor V Yatsenko1

  • 1Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia.

Molecules (Basel, Switzerland)
|June 27, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed novel pH-sensitive multiliposomal containers for rapid drug release. These biodegradable, low-cytotoxicity carriers show great potential for targeted drug delivery in biomedical applications.

Keywords:
bioactive compoundcontrolled drug deliverycytotoxicityliposomemolecular switchmultiliposomalnanocontainerpH-sensitivepolyethylene glycol

More Related Videos

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.2K
On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
09:45

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

2.8K

Related Experiment Videos

Last Updated: May 10, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

24.2K
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.2K
On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
09:45

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

2.8K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Developing stimuli-sensitive drug delivery systems remains challenging.
  • Existing pH-sensitive containers often lack rapid response and efficient drug release.
  • Targeted delivery to specific sites like tumors requires advanced carrier design.

Purpose of the Study:

  • To design and characterize novel pH-sensitive multiliposomal containers.
  • To achieve rapid drug release in response to small pH variations.
  • To enhance drug delivery efficiency and therapeutic effects via targeted mechanisms.

Main Methods:

  • Synthesis of pH-sensitive ampholytic derivatives of cholan-24-oic acid.
  • Incorporation into anionic liposomes and surface functionalization with PEG-coated cationic liposomes.
  • Optimization of multiliposomal complex size (250-400 nm) for passive targeting.
  • Evaluation of drug release rates under varying pH conditions.
  • Assessment of biodegradability and cytotoxicity.

Main Results:

  • The developed multiliposomal complexes exhibited rapid release of encapsulated substances upon pH alteration.
  • The pH-sensitive ampholytic derivative facilitated quick cargo release in low pH environments.
  • Optimized particle size supported passive targeting capabilities.
  • The multiliposomal complexes demonstrated biodegradability and low cytotoxicity.

Conclusions:

  • Novel pH-sensitive multiliposomal containers offer rapid, triggered drug release.
  • These carriers are suitable for targeted delivery to acidic environments like tumors.
  • The developed system shows significant promise for advanced biomedical applications.