Mucoadhesive PVA Film for Sustained Resveratrol Delivery: Formulation, Characterization, and Release Profile

Area of Science:

• Materials Science
• Biomedical Engineering
• Pharmacology

Background:

• Oral mucosal wounds require advanced dressings for effective healing.
• Resveratrol (RSV) and Reynoutria japonica extract possess therapeutic properties.
• Polyvinyl alcohol (PVA) offers a suitable base for mucoadhesive drug delivery systems.

Purpose of the Study:

• To develop and optimize PVA-based polymeric films incorporating resveratrol (RSV) or Reynoutria japonica extract.
• To evaluate the physicochemical properties and therapeutic applicability of these films as oral mucosal wound dressings.
• To compare the performance of pure RSV with Reynoutria japonica extract in the developed film formulations.

Main Methods:

• Solvent casting method was employed for film fabrication.
• Films were characterized for thickness, weight, color, flexibility, elasticity, and mucoadhesive strength.
• In vitro release studies were conducted in water and simulated saliva.
• Hydrophilicity and pH were assessed to determine physiological compatibility.

Main Results:

• Optimized PVA films (FR2 and FE2) demonstrated excellent mucoadhesive properties.
• Favorable drug release profiles were observed in both water and saliva.
• Films exhibited suitable physicochemical characteristics, including hydrophilicity and physiological pH.
• Formulations containing RSV and Reynoutria japonica extract showed significant potential for oral wound healing.

Conclusions:

• PVA-based films with resveratrol or Reynoutria japonica extract are promising candidates for oral mucosal wound dressings.
• The developed films possess desirable mucoadhesive and release characteristics for dental applications.
• These novel dressings could enhance the efficacy of local therapies in dentistry.