Brain Neurotrophins and Plant Polyphenols: A Powerful Connection
Marco Fiore1, Sergio Terracina2, Giampiero Ferraguti2
1Institute of Biochemistry and Cell Biology (IBBC-CNR), c/o Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
Molecules (Basel, Switzerland)
|June 27, 2025
Summary
Dietary plant polyphenols can enhance brain health by modulating neurotrophin signaling, crucial for neuronal function and protecting against neurodegenerative diseases. This review explores mechanisms and therapeutic potential for cognitive and mood disorders.
Area of Science:
- Neuroscience
- Nutritional Science
- Pharmacology
Background:
- Neurotrophins like NGF and BDNF are vital for neuronal health, and their dysregulation is linked to neurodegenerative and mood disorders.
- Dietary plant polyphenols possess antioxidant, anti-inflammatory, and anti-apoptotic properties beneficial for brain health.
Purpose of the Study:
- To review the evidence linking plant polyphenols to brain neurotrophin signaling.
- To elucidate molecular mechanisms through which polyphenols modulate neurotrophin pathways.
- To explore therapeutic applications for neurodegenerative, mood, and addiction disorders.
Main Methods:
- Narrative review of existing scientific literature.
- Analysis of molecular pathways involved in polyphenol-neurotrophin interactions.
- Examination of findings from clinical and animal studies.
Main Results:
- Polyphenols regulate neurotrophin signaling via anti-inflammatory, antioxidant, and anti-apoptotic effects.
- Key mechanisms include CREB activation, epigenetic modulation, and reduced oxidative stress.
- Polyphenol-induced neurotrophin upregulation supports synaptic function, neuronal integrity, and cognitive processes.
Conclusions:
- Plant polyphenols show significant potential in promoting brain health and counteracting neurodegeneration.
- Polyphenols may offer therapeutic benefits for addiction and mood disorders.
- Future research should focus on bioavailability, dietary strategies, and personalized nutrition.
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