Prevalence of Sexual Dysfunction with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS): An Updated...

Area of Science:

• Urology
• Sexual Medicine
• Public Health

Background:

• Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition characterized by significant urogenital symptoms.
• Sexual dysfunction is a commonly reported and impactful comorbidity in men diagnosed with CP/CPPS.

Purpose of the Study:

• To determine the overall prevalence of sexual dysfunction in men with CP/CPPS.
• To specifically assess the prevalence of desire, arousal, orgasm, and pain-related sexual disorders.
• To quantify the prevalence of erectile dysfunction (ED) and premature ejaculation (PE) in this population.

Main Methods:

• Systematic literature review adhering to MOOSE guidelines.
• Searched four major electronic databases (PubMed, Embase, Web of Science, Google Scholar) from January 2000 to 2025.
• Included observational studies reporting sexual dysfunction prevalence in CP/CPPS patients; employed random-effects model for pooled prevalence estimation.

Main Results:

• Analyzed 26 studies with 20,127 participants.
• Pooled prevalence of overall sexual dysfunction was 59% (95% CI: 34-81%).
• Pooled prevalence for erectile dysfunction (ED) was 34% (95% CI: 26-42%), and for premature ejaculation (PE) was 35% (95% CI: 22-49%).

Conclusions:

• This meta-analysis confirms a high prevalence of sexual dysfunction, including ED and PE, in men with CP/CPPS.
• The findings underscore the substantial burden of sexual health issues associated with CP/CPPS.
• Significant heterogeneity necessitates further research to identify contributing factors and guide targeted interventions.