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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
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Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

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Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Articles linked to this work by shared authors, journal, and citation graph.

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Hospital costs attributable to further fracture, reoperation, and death during the first year following hip fracture in England : a nationwide cohort study.

The bone & joint journal·2026
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Guidance for the assessment of the dietary intake and gastrointestinal or nutrition impact symptoms etiologic criterion of Global Leadership Initiative on Malnutrition: A modified-Delphi study.

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Cross-modal interaction of human alpha activity does not reflect inhibition of early sensory processing in a frequency-tagging study using EEG and MEG.

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Reoperation in the year following a hip fracture : a nationwide cohort study in England.

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Related Experiment Video

Updated: Sep 18, 2025

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The SIMPLER Nutrition Pathway for Fragility Fractures: A Quality Improvement Initiative.

Jack J Bell1,2, Olof Gudny Geirsdottir1,2, Antony Johansen2,3

  • 1Faculty of Food Science and Nutrition, School of Health at the University of Iceland, 102 Reykjavik, Iceland.

Nutrients
|June 27, 2025
PubMed
Summary

Malnutrition worsens outcomes for older adults with fragility fractures. The SIMPLER Nutrition Pathway and toolkit were co-created and tested to improve evidence-based nutrition care globally for these patients.

Keywords:
fragility fracturehip fracturehospitalsimplementationimprovementmalnutritionnutritional supportprotocolquality improvement

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Area of Science:

  • Geriatric Medicine
  • Nutrition Science
  • Quality Improvement in Healthcare

Background:

  • Malnutrition significantly increases complications, functional decline, and mortality in older adults with fragility fractures.
  • Existing evidence supports early, interdisciplinary nutrition care, particularly for hip fractures, yet implementation remains suboptimal globally.
  • A gap exists between recommended nutrition interventions and their actual application in fragility fracture care.

Purpose of the Study:

  • To co-create and test a pathway and toolkit (SIMPLER) for delivering evidence-based nutrition care in global fragility fracture settings.
  • To address the identified evidence-practice gap in nutrition interventions for patients with fragility fractures.
  • To develop a scalable and adaptable framework for improving nutrition care in this vulnerable population.

Main Methods:

  • A multiphase, co-creation quality improvement initiative (2018-2025) guided by the Knowledge-to-Action framework.
  • Development and iterative refinement of the SIMPLER Pathway and toolkit through expert and clinical team engagement.
  • Pilot testing in five hospitals across four countries, utilizing action-reflection cycles and the Model for Improvement.

Main Results:

  • Over 100 co-creation activities involved staff and patients in refining the SIMPLER pathway.
  • Global surveys, audits, and interviews confirmed a widespread evidence-practice gap in nutrition care for fragility fractures.
  • Pilot testing led to context-tailored improvements, with 46 healthcare services in 23 countries committing to SIMPLER implementation.

Conclusions:

  • The SIMPLER Nutrition Pathway offers a scalable and adaptable framework for evidence-based nutrition care in fragility fracture settings.
  • The co-creation approach facilitated the development of a practical toolkit addressing real-world implementation challenges.
  • Global adoption is increasing, indicating the potential for widespread impact on patient outcomes.