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Exploring the Potential Association Between Inhaled Corticosteroid and Face Aging Risk: A Mendelian Randomization
Junpeng Li1, Yaqiong Liu2, Gujie Wu2
1Department of Surgery Tohoku, University Graduate School of Medicine, Sendai 980-8575, Japan.
Inhaled corticosteroids (ICSs) may accelerate facial aging by affecting ORMDL3 gene expression and 5-hydroxylysine metabolism. Further research is needed to confirm these potential effects on skin aging.
Area of Science:
- Genetics
- Pharmacology
- Dermatology
Background:
- Asthma affects over 300 million globally, with inhaled corticosteroids (ICSs) as primary treatment.
- Long-term ICS use may cause side effects, including skin changes.
- Investigating potential links between ICSs and aging is crucial.
Purpose of the Study:
- To explore the potential causal relationship between inhaled corticosteroids (ICSs) and facial aging.
- To identify mediating factors and genetic mechanisms linking ICSs to facial aging.
- To investigate the role of ORMDL3 gene expression and DNA methylation in this association.
Main Methods:
- Utilized Mendelian randomization (MR) and colocalization analyses with large-scale genetic and phenotypic data.
- Integrated data from DrugBank, DGIdb, cis-eQTL, GWAS for facial aging, and plasma metabolomics.
- Analyzed DNA methylation QTL (mQTL) data to explore epigenetic regulation.
Main Results:
- MR analysis indicated a significant association between genetically proxied ICSs (ORMDL3) and facial aging in Europeans.
- 5-Hydroxylysine was identified as a potential mediator in the relationship between ICSs and facial aging.
- Novel DNA methylation sites of ORMDL3 showed pleiotropic associations with facial aging, suggesting regulatory roles.
Conclusions:
- Findings suggest ICSs may influence facial aging via ORMDL3 upregulation and altered 5-hydroxylysine metabolism.
- These results hypothesize a novel mechanism linking asthma medication to skin aging.
- Further pharmacological and clinical studies are warranted to validate these exploratory findings.
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