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[Blood transfusion and kidney transplantation]
Schweizerische Medizinische Wochenschrift
|May 21, 1977
Summary
The historical non-transfusion policy for kidney transplant recipients has failed. Evidence shows transfused patients experience improved kidney allograft function, challenging current practices.
Area of Science:
- Nephrology
- Immunology
- Transplantation Science
Background:
- The established non-transfusion policy for kidney allograft recipients has demonstrated a lack of success in recent years.
- Clinical observations indicate improved transplant function in kidney allograft recipients who have received blood transfusions.
Purpose of the Study:
- To evaluate the efficacy of blood transfusions on kidney allograft function.
- To challenge the prevailing non-transfusion policy in potential kidney transplant recipients.
Main Methods:
- Review of clinical evidence regarding kidney allograft function in transfused versus non-transfused recipients.
- Analysis of animal experimental data comparing graft function after blood transfusions under controlled conditions.
Main Results:
- Clinical data from multiple centers (Basel, Geneva) confirm improved outcomes for transfused recipients of first cadaver kidney transplants.
- Animal studies, when mimicking human kidney transplantation conditions, show blood transfusions typically prolong graft function, not accelerate rejection.
Conclusions:
- The non-transfusion policy for kidney allograft recipients is not supported by current clinical and experimental evidence.
- A more liberal transfusion approach for potential kidney graft recipients is warranted.
- Further research is needed to establish optimal host conditioning protocols while mitigating transfusion risks.