Current and Emerging Therapies for Eosinophilic Esophagitis (EoE): A Comprehensive Review

Area of Science:

• Immunology
• Gastroenterology
• Allergy

Background:

• Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disease with increasing prevalence in children and adults.
• Pathogenesis involves a complex interplay of genetic susceptibility and environmental factors leading to esophageal inflammation.
• Symptoms include esophageal dysfunction, and diagnosis is confirmed by increased esophageal eosinophils.

Purpose of the Study:

• To provide an overview of Eosinophilic Esophagitis (EoE).
• To discuss current and emerging therapeutic strategies for EoE.
• To highlight the evolving treatment landscape for this condition.

Main Methods:

• Literature review of current research and clinical guidelines for EoE.
• Analysis of established and novel pharmacologic treatments.
• Examination of the role of biologics in EoE management.

Main Results:

• First-line treatments for EoE include proton pump inhibitors, topical steroids, and dietary elimination diets.
• Dupliumab is a recently approved biologic agent for EoE treatment.
• Several other investigational biologic agents targeting distinct immune pathways are in development.

Conclusions:

• EoE is a significant and increasingly recognized chronic immune disorder.
• The therapeutic options for EoE are expanding, offering new hope for patients.
• Ongoing research into novel biologic agents promises further advancements in managing EoE.