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Formulation and Characterization of Bone-Targeting Vancomycin-Loaded Liposomes.

Basel Karzoun1, Wala'a Albenayan1, Shilpa Raut2

  • 1Department of Pharmaceutical Sciences, MCPHS-University, 179 Longwood Avenue, Boston, MA 02115, USA.

Pharmaceutics
|June 27, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed targeted liposomes carrying vancomycin, an antibiotic. These novel bone-targeting liposomes show enhanced affinity for bone tissue, offering potential for treating bone infections.

Keywords:
alendronateboneliposomesosteomyelitistargetingvancomycin

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Osteomyelitis and bone infections require effective antibiotic delivery.
  • Liposomal carriers offer potential for targeted drug delivery.
  • Vancomycin is a critical antibiotic for treating Gram-positive bacterial infections.

Purpose of the Study:

  • To formulate and characterize bone-targeting vancomycin-loaded liposomes.
  • To enhance the delivery of vancomycin to bone tissue.
  • To evaluate the bone affinity of the developed liposomal carrier.

Main Methods:

  • Liposomes were formulated using DSPC, cholesterol, and DCP.
  • Vancomycin was encapsulated using dehydration-rehydration and thin-film hydration methods.
  • Sodium alendronate was conjugated to DSPE-PEG-COOH to create a bone-targeting moiety.

Main Results:

  • Successful conjugation of alendronate to liposome surface confirmed by IR spectroscopy.
  • In vitro studies showed preferential binding of targeted liposomes to hydroxyapatite.
  • Ex vivo studies demonstrated enhanced binding of targeted liposomes to mouse tibial bone tissue.

Conclusions:

  • Surface-modified vancomycin-loaded liposomes exhibit significantly enhanced bone affinity.
  • This formulation holds great potential for targeted antibiotic delivery to infected bones.
  • The developed liposomal carrier represents a promising strategy for treating bone infections.