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Related Experiment Video

Updated: Sep 18, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Do flexible ureteroscopies affect renal function?

Murad Asali^1,2, Osman Hallak¹, Galeb Asali³

¹Urology Department, Barzilai University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

|June 27, 2025

Summary

This summary is machine-generated.

Flexible ureteroscopy (f-URS) for upper urinary tract stones generally shows minimal impact on renal function. Dynamic renal scans before and after f-URS can help identify high-risk patients who may experience changes.

Keywords:

DTPA MAG3 RIRS-retrograde intrarenal surgery Renal scan renal function

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Area of Science:

Urology
Nephrology
Medical Imaging

Background:

Flexible ureteroscopy (f-URS) is a common procedure for treating upper urinary tract stones (UUTS).
Assessing the impact of f-URS on renal function is crucial for patient management.
Dynamic renal scans, such as DTPA or MAG3, provide functional information about the kidneys.

Purpose of the Study:

To evaluate the effect of flexible ureteroscopies on renal function.
To identify potential changes in differential renal function post-procedure using dynamic renal scans.

Main Methods:

Retrospective analysis of 101 renal units undergoing f-URS for UUTS between April 2010 and March 2024.
Pre- and post-operative dynamic renal scans (DTPA or MAG3) were performed to assess differential renal function.
Patients were categorized based on renal function changes: worsened (>10%), improved (>10%), or unaffected (≤10% change).

Main Results:

The majority of patients (94.1%) experienced no significant change in renal function post-f-URS.
A small percentage of patients showed either a decline (3%) or improvement (3%) in differential renal function (>10%).
Mean pre-operative renal function was 47.3% and post-operative was 48%, indicating stability.

Conclusions:

Flexible ureteroscopy demonstrates minimal to no adverse impact on overall renal function for UUTS treatment.
Dynamic renal scans may be beneficial for risk stratification in select patients undergoing f-URS.