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The Role of the TRIM Family in Lung Cancer Development: An Emerging Player with Therapeutic Potential
Jinxin Li1,2, Yiling Wang1,2, Jinbai Huang1,2
1Nuclear Medicine Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, 434023, China.
Abstract:
Lung cancer is one of the most prevalent malignancies and a leading cause of cancer-related deaths worldwide. E3 ubiquitin ligase activity is a common feature of most TRIM proteins, highlighting the family's critical role in regulating the biological behaviors of tumor cells and influencing various cellular physiological activities, including apoptosis, innate immunity, development, and intracellular signaling. In lung cancer, certain TRIM proteins function either as oncoproteins or cancer suppressors. This review explores the unique function of TRIM in lung cancer development, focusing on the molecular processes of TRIM proteins. Finally, we provide an overview of recent advancements in the prognosis and therapeutic strategies for lung cancer involving TRIM proteins.
Insights
This review details the role of TRIM proteins in lung cancer, acting as oncoproteins or tumor suppressors. It covers their molecular functions, and advances in lung cancer prognosis and therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Lung cancer is a major global health concern, responsible for significant mortality.
- TRIM proteins, characterized by E3 ubiquitin ligase activity, are crucial regulators of cellular processes.
- Dysregulation of TRIM proteins contributes to tumorigenesis in various cancers, including lung cancer.
Purpose of the Study:
- To review the multifaceted roles of TRIM proteins in lung cancer development.
- To elucidate the molecular mechanisms underlying TRIM protein function in lung cancer.
- To summarize recent progress in lung cancer prognosis and therapeutic strategies targeting TRIM proteins.
Main Methods:
- Literature review of studies on TRIM proteins and lung cancer.
- Analysis of molecular pathways involving TRIM proteins in cancer biology.
- Synthesis of current research on TRIM-related lung cancer diagnostics and therapeutics.
Main Results:
- TRIM proteins exhibit dual roles in lung cancer, functioning as oncogenes or tumor suppressors.
- Specific TRIM proteins influence key cellular processes like apoptosis, immunity, and signaling pathways in lung cancer.
- Understanding TRIM protein functions provides insights into lung cancer pathogenesis.
Conclusions:
- TRIM proteins are critical players in lung cancer progression and development.
- Targeting TRIM proteins offers potential for novel lung cancer therapeutic strategies.
- Further research into TRIM protein mechanisms can improve lung cancer patient outcomes.
