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The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Nano-Toothbrush for Noninvasive Control of Periodontitis.

X Liu1, Y Liang1, Z Li

  • 1Department of Periodontology/Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases.

Journal of Dental Research
|June 27, 2025
PubMed
Summary
This summary is machine-generated.

A novel nano-toothbrush effectively removes oral biofilms using ultrasound-activated nanoparticles. This noninvasive approach shows promise for treating periodontitis by targeting pathogenic bacteria while preserving the oral microbiome and demonstrating biosafety.

Keywords:
Porphyromonas gingivalisbiofilmnanoparticlesperiodontal diseasereactive oxygen speciestherapeutics

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Area of Science:

  • Nanotechnology
  • Biomaterials
  • Oral Medicine

Background:

  • Periodontitis is a common oral disease with limited treatment options.
  • Current management involves mechanical debridement and antibiotics, which have limitations.

Purpose of the Study:

  • To introduce a noninvasive "nano-toothbrush" for oral biofilm removal.
  • To evaluate the efficacy and biosafety of this nanotherapeutic approach.

Main Methods:

  • Developed a piezocatalytic nanoparticle-constructed "nano-toothbrush".
  • Tested ex vivo biofilm removal from periodontitis patients.
  • Assessed biosafety using mouse fibroblasts and human oral epithelial cells.
  • Conducted in vivo studies in a rat periodontitis model.

Main Results:

  • The nano-toothbrush effectively disrupted oral biofilms and inhibited pathogenic bacteria like *Porphyromonas gingivalis*.
  • Demonstrated minimal damage to host cells, confirming biosafety.
  • Significantly suppressed alveolar bone resorption and reduced inflammation in vivo.
  • Preserved the diversity of the oral microbiome during treatment.

Conclusions:

  • The piezocatalytic nano-toothbrush offers a promising noninvasive strategy for oral biofilm removal.
  • This nanotherapeutic approach presents new perspectives for periodontitis treatment.
  • The technology shows potential for managing other plaque-induced oral diseases.