Related Experiment Video
Updated: Sep 18, 2025
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
Association between dietary inflammatory index and asthmatic patients with sleep disorders in American adults, NHANES
Zhouzhou Lu1,2, Yujing Gu1,2, Yun Zhao1
1Nursing Department, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
Background:
Chronic airway inflammation, recognized as the core pathological mechanism of asthma, may disrupt circadian rhythms through neuroimmune modulation mediated by inflammatory mediators. Emerging evidence suggests a markedly elevated prevalence of sleep disturbances among asthma patients, while dietary patterns modulating systemic inflammatory balance present feasible intervention targets. However, the association between Dietary Inflammatory Index (DII) and comorbid sleep disorders in asthma remains underexplored.
Method:
This cross-sectional study analyzed data from 4,443 asthmatic adults with sleep disorders in NHANES (2005-2020). DII scores were calculated using 28 food parameters from two 24-h dietary recalls. Weighted multivariable logistic regression models were employed to examine DII-sleep disturbance associations with sequential adjustment for demographic, lifestyle, and clinical confounders. Restricted cubic spline (RCS) analysis evaluated nonlinear relationships and inflection points. Gender heterogeneity and subgroup interactions were assessed through stratified analyses.
Result:
Multivariable analysis demonstrated significant dose-response relationships between elevated DII and sleep disturbance risk (P for trend <0.001). Participants in the highest DII quartile (Q4) demonstrated 47% increased risk compared to Q1 (OR:1.47, 95%CI:1.19-1.83). Full adjustment attenuated this association (Model 2 OR = 1.27, 0.99-1.62; p = 0.06), though borderline significance persisted (P for trend = 0.05). RCS analysis revealed a U-shaped nonlinear association (inflection point: DII = 1; p < 0.05) with significant gender heterogeneity. Males exhibited pronounced U-shaped trends (p < 0.05), contrasting with linear patterns in females (p > 0.05). Poverty-income ratio demonstrated significant interaction (p < 0.05), while other subgroups showed no significant interaction (p > 0.05).
Conclusion:
The U-shaped DII-sleep disturbance underscores the critical importance of implementing anti-inflammatory dietary strategies in comprehensive asthma management.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
Related Concept Videos
01:29Asthma-I: Introduction
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:26Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:24Asthma-III: Symptoms and Complications
Classification of Asthma
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
02:20Correlations