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Updated: Sep 17, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Opioid analgesics for sedation-based gastrointestinal endoscopy
Wei-Lin Yang1,2, Xin-Yu Zhou1,3, Wen-Cai Jiang1
1Department of Anesthesiology, Deyang People's Hospital, Deyang 618000, Sichuan Province, China.
Summary
Opioid analgesics significantly improve gastrointestinal endoscopy by reducing pain and sedative doses. Novel agents like oliceridine show promise for enhanced patient comfort and procedural safety.
Area of Science:
- Gastroenterology
- Anesthesiology
- Pharmacology
Background:
- Gastrointestinal endoscopy, while common, can cause patient distress and adverse events.
- Sedation and anesthesia improve safety and quality but may require adjuncts.
- Opioids are effective adjuvants for sedation during endoscopic procedures.
Purpose of the Study:
- To review the role of opioid analgesics in gastrointestinal endoscopy.
- To summarize benefits including pain reduction and decreased sedative requirements.
- To discuss commonly used and novel opioid agents.
Main Methods:
- This is a narrative review.
- Literature search on opioid use in gastrointestinal endoscopy.
- Analysis of opioid pharmacology and clinical applications.
Main Results:
- Opioids reduce visceral pain and throat irritation.
- They allow for lower sedative doses, enhancing safety.
- Fentanyl, sufentanil, and dezocine are frequently used; oliceridine is a promising new option.
Conclusions:
- Opioid analgesics are valuable in gastrointestinal endoscopy.
- Novel opioids like oliceridine warrant further clinical investigation.
- Optimizing opioid use can improve patient experience and procedural outcomes.
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