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Updated: Sep 17, 2025

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Fibroblast growth factor 8: Multifaceted role in development and developmental disorder.

Huamin Yin1,2, Lian Duan2, Zhendong Wang3

  • 1Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.

Genes & Diseases
|June 27, 2025
PubMed
Summary

Fibroblast growth factor 8 (FGF8) is vital for embryonic development, regulating cell functions and organogenesis. Aberrant FGF8 signaling causes severe developmental abnormalities, impacting multiple organ systems.

Keywords:
Developmental disordersEmbryonic developmentFGF8OrganogenesisSingle cell RNA sequencing

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Area of Science:

  • Developmental Biology
  • Molecular Signaling
  • Genetics

Background:

  • Fibroblast growth factor 8 (FGF8) is a secreted signaling molecule essential for embryonic development.
  • FGF8 regulates critical cellular processes including survival, proliferation, migration, and differentiation.
  • Its dynamic expression pattern is crucial for the proper formation of various embryonic structures.

Purpose of the Study:

  • To comprehensively review FGF8 expression patterns in humans and mice.
  • To summarize FGF8's role in the development of craniofacial structures, limbs, cardiovascular and urogenital systems, nephrogenesis, lungs, and brain.
  • To explore developmental abnormalities linked to dysregulated FGF8 signaling.

Main Methods:

  • Literature review of studies on FGF8 expression and function.
  • Analysis of FGF8's involvement in diverse embryonic tissues.
  • Compilation of data on FGF8-related developmental disorders.

Main Results:

  • FGF8 exhibits dynamic spatiotemporal expression during embryogenesis.
  • FGF8 is indispensable for craniofacial, limb, organ, and brain development.
  • Dysregulation of FGF8 leads to multiorgan abnormalities, including skeletal defects, ciliopathies, and holoprosencephaly.

Conclusions:

  • FGF8 is a key regulator of embryonic organogenesis and tissue development.
  • Precise control of FGF8 localization and dosage is critical for normal development.
  • Aberrant FGF8 signaling underlies a spectrum of congenital abnormalities.