[Anticancer therapy of the genito-urinary tract and infection]

Infectious diseases will often occur in the genito-urinary tract cancer cases, who are undergone the therapy of anticancer drugs. The organisms isolated from these cases are almost so-called opportunistic pathogens. beta-lactam antibiotics are given frequently to these cases, because of the mechanisms of the antibacterial activity. The effects of beta-lactams on macrophage phagocytic and killing activity of P. aeruginosa are examined. Cells pretreated with Carbenicillin, Cefotaxime, Ceftazidime or AC-1370 caused a greater degree of decline of viable cells than the untreated control cells. Intravesical instillation of Adriamycin in superficial bladder tumor are very useful, but chemical-cystitis will find sometimes as side effect. Adriamycin 60 mg, Stronger neo-minophagen C 20 ml and saline 20 ml instill together to 24 cases once everyday for 10-44 days. Drop-out cases by chemical-cystitis are only 3. The detailed results will be reported elsewhere.