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Clinical effects of methylphenidate hydrochloride extended-release tablets on improvement of intelligence and

Wenjin Huang1, Yanyan Wang1

  • 1Department of Pediatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China.

African Journal of Reproductive Health
|June 27, 2025
PubMed

Insights

Methylphenidate hydrochloride extended-release tablets significantly improved intelligence, behavior, and quality of life in children with attention deficit hyperactivity disorder (ADHD). Treatment also increased key neurotransmitter levels in these children.

Area of Science:

  • Neuroscience
  • Pediatric Psychiatry
  • Pharmacology

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Effective treatments are crucial for managing ADHD symptoms and improving long-term outcomes.
  • Methylphenidate is a widely prescribed stimulant medication for ADHD.

Purpose of the Study:

  • To investigate the effects of methylphenidate hydrochloride extended-release tablets on intelligence and behavior in children with ADHD.
  • To assess the impact of this treatment on neurotransmitter levels.
  • To evaluate changes in self-awareness and quality of life.

Main Methods:

  • A randomized controlled trial involving 120 children diagnosed with ADHD.
  • Participants were divided into a treatment group (methylphenidate hydrochloride extended-release tablets) and a placebo control group.
  • Assessments of intelligence, behavior, self-awareness, quality of life, and neurotransmitter levels were conducted over 12 weeks.

Main Results:

  • The methylphenidate group showed significant improvements in intelligence, self-awareness, and quality of life compared to the placebo group.
  • Behavioral scores and clinical symptoms were reduced in the treatment group.
  • Levels of 5-hydroxytryptamine, norepinephrine, and dopamine were elevated in the methylphenidate group post-treatment.

Conclusions:

  • Methylphenidate hydrochloride extended-release tablets are effective in improving cognitive function, attention, and behavior in children with ADHD.
  • The medication positively impacts self-awareness and quality of life.
  • Treatment with methylphenidate hydrochloride leads to favorable changes in monoamine neurotransmitter levels.

Keywords:
, monoamine neurotransmittersAttention deficit hyperactivity disorderchildrenmethylphenidate hydrochloride prolonged-release tablet

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