Related Experiment Video
Updated: Sep 17, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Chan-Evans-Lam Cu(II)-Catalyzed C-O Cross-Couplings: Broadening Synthetic Access to Functionalized Vinylic Ethers
San L Pham1, Frank E McDonald1
1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Abstract:
We report a general and effective Cu(OAc)2-catalyzed C-O cross-coupling synthesis of di- and trisubstituted vinylic ethers, using a combination of N-isopropylimidazole ligand and dicumyl peroxide as stoichiometric oxidant. This method couples functionalized vinylic pinacolboronates with various 1° and 2° alcohols to provide single-step syntheses of novel and structurally complex vinylic ethers. The optimized conditions do not require excess alcohol reactant and substantially suppress competing side reactions.
Related Concept Videos
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Acid-Catalyzed Ring-Opening of Epoxides
Base-Catalyzed Ring-Opening of Epoxides
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Cycloaddition Reactions: Overview
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement

