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Related Experiment Video

Updated: Sep 17, 2025

Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition
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How Propolis Prevents Nicotine-Related Lung Damage.

Imran Ozdemir1, Nuray Bayar Muluk2, Mustafa B Karahan3

  • 1Department of Pulmonology, Medical Faculty, Üsküdar University, Istanbul.

The Journal of Craniofacial Surgery
|June 27, 2025
PubMed
Summary

Propolis extract significantly reduced nicotine-induced lung damage in rats by decreasing inflammation and tissue injury. Further human studies are recommended to confirm these protective effects.

Keywords:
Air pollutionbronchial damagelung injurynicotinepropolis extract

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Area of Science:

  • Pulmonology
  • Toxicology
  • Pharmacology

Background:

  • Nicotine exposure is a significant risk factor for pulmonary damage.
  • Propolis, a natural resinous mixture, possesses antioxidant and anti-inflammatory properties.
  • Investigating natural compounds for mitigating toxicant-induced organ damage is crucial.

Purpose of the Study:

  • To evaluate the protective efficacy of propolis extract against nicotine-induced lung injury in a rat model.
  • To assess the histological changes in lung tissue following nicotine exposure and propolis treatment.

Main Methods:

  • Wistar albino rats were divided into two groups: nicotine control and nicotine + propolis extract.
  • Nicotine (10 mg/kg) was administered daily for 8 weeks.
  • Propolis extract (200 mg/kg/day) was administered orally to the treatment group concurrently.

Main Results:

  • The nicotine + propolis extract group exhibited significantly reduced bronchiole damage, hemorrhage, vascular congestion, and cellular infiltration compared to the nicotine group.
  • Histological examination revealed diminished inflammation and preserved alveolar architecture in rats treated with propolis extract.
  • Nicotine exposure alone led to severe inflammation, bronchial epithelial damage, and vascular congestion.

Conclusions:

  • Propolis extract demonstrates a protective effect against nicotine-induced pulmonary damage.
  • The mechanism may involve the Nrf2/HO-1 signaling pathway and suppression of iNOS and TNF-α.
  • Human clinical trials are warranted to explore propolis's therapeutic potential for nicotine-related lung damage.