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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

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Related Experiment Video

Updated: Jun 14, 2026

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

474

A Prospective, Multicentre Case-Control Trial Examining Factors That Explain Variable Clinical Performance in Post

Pam Dawson1, Amanda Fullerton1, Harish Krishnamoorthi2

  • 1Cochlear Limited, Sydney, NSW, Australia.

Trends in Hearing
|June 27, 2025
PubMed
Summary

Poor cochlear implant performance in adults is linked to specific factors. Underfitted sound processor maps, higher neural thresholds, and longer refractory times significantly predict worse word scores.

Keywords:
cochlear implantcognitionelectrode placementneural healthpredictive factorssound processor mappingspeech perception

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Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
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Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

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Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process
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Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process

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Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
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Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

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Area of Science:

  • Audiology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Cochlear implants (CI) are crucial for hearing restoration in adults.
  • Variability in CI outcomes necessitates understanding contributing factors.
  • Differentiating performance groups aids in targeted research.

Purpose of the Study:

  • To identify factors predicting word recognition performance in experienced adult CI users.
  • To compare systematically measured sound processor maps with patient's own maps.
  • To investigate the role of neural, cognitive, and device-related factors.

Main Methods:

  • Compared 72 poorer-performing CI users with 77 better-performing users.
  • Assessed sound processor mapping, electrode placement (modiolar distance, insertion angle, scalar translocation).
  • Measured neural health (bipolar thresholds, ECAP measures like IPG effect, refractory time), impedance, and cognitive function.

Main Results:

  • Predictor variables explained 33-60% of performance variability.
  • Underfitted sound processor maps, higher bipolar thresholds, longer total refractory time, and greater interphase gap (IPG) offset predicted poorer performance.
  • Scalar translocation and cognitive factors also significantly predicted outcomes.

Conclusions:

  • Specific audiological and neural parameters significantly impact CI performance in adults.
  • Optimizing sound processor maps and addressing neural health are key for improving outcomes.
  • Further research into electrode placement and cognitive influences is warranted.