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Updated: Sep 17, 2025
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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
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[DRESS syndrome due to antituberculosis drugs. Review and comments]
Laura Lagrutta1,2, Ana Gamberale1, Bruno Bartoletti1
1Hospital de Infecciosas Dr. Francisco J. Muñiz, Buenos Aires, Argentina.
Medicina
|June 27, 2025
Summary
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) from antituberculosis drugs, especially rifampicin, is a severe adverse reaction. Early identification and multidisciplinary management are vital to prevent fatal complications.
Area of Science:
- Pharmacology
- Immunology
- Infectious Diseases
Context:
- DiHS/DRESS is a rare but severe adverse reaction to antituberculosis drugs.
- Rifampicin is the most frequently implicated drug.
- This syndrome affects both adults and children, potentially compromising treatment success and patient survival.
Purpose:
- To review the literature on DiHS/DRESS caused by antituberculosis drugs.
- To analyze management strategies based on accumulated experience in a reference tuberculosis center.
Summary:
- DiHS/DRESS involves hypersensitivity to drugs, presenting with fever, rash, eosinophilia, adenopathy, and visceral involvement.
- Rapid progression can lead to multiorgan failure and death.
- Management requires a multidisciplinary team approach due to the syndrome's heterogeneity and severity.
Impact:
- Highlights the critical need for early diagnosis and intervention in DiHS/DRESS.
- Emphasizes the importance of a multidisciplinary approach for managing this life-threatening condition.
- Informs clinical practice regarding the risks associated with antituberculosis drug therapy.
Keywords:
DRESS syndromeDiHS/DRESSadverse reactionsantituberculosis drugseosinophiliahypersensitivityMore Related Videos
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