Related Experiment Video

Updated: Sep 17, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

11.6K

Clinical phenotypes and renal outcomes in PLA2R-associated membranous nephropathy: a multi-center cohort study with

Jing Miao1, Jaleh Zand1, Lisa Vaughan2

  • 1Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|June 27, 2025
PubMed
Abstract

Insights

Identifying distinct clinical phenotypes in phospholipase A2 receptor-associated membranous nephropathy (PLA2R-MN) is key. Phenotype-based risk stratification can improve patient outcomes and treatment precision for this common cause of nephrotic syndrome.

Area of Science:

  • Nephrology
  • Immunology
  • Internal Medicine

Background:

  • Phospholipase A2 receptor (PLA2R)-associated membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults.
  • Understanding clinical phenotypes is crucial for predicting renal outcomes in PLA2R-MN.

Purpose of the Study:

  • To investigate the relationship between clinical phenotypes and renal outcomes in PLA2R-positive MN.
  • To explore the potential for phenotype-based treatment stratification in PLA2R-MN.

Main Methods:

  • Retrospective, multi-center cohort study of 178 patients with PLA2R-positive MN.
  • Unsupervised cluster analysis to group patients based on clinicopathological characteristics.
  • Primary outcomes included remission of nephrotic syndrome and progression to end-stage kidney disease (ESKD) or death.

Main Results:

  • Three distinct patient clusters were identified, with varying remission rates (72% in cluster 1, 50% in cluster 2, 54% in cluster 3).
  • Elevated anti-PLA2R levels and proteinuria predicted reduced remission, while high-density lipoprotein levels were protective.
  • ESKD-free survival significantly differed across the identified clusters.

Conclusions:

  • Unsupervised clustering revealed distinct clinical phenotypes in PLA2R-positive MN, each linked to different renal prognoses.
  • Phenotype-based risk stratification may enhance treatment precision and improve patient outcomes in PLA2R-MN.
  • This approach could potentially reduce treatment-related adverse effects.
Keywords:
PLA2R-associated nephropathyclinical phenotypingmembranous nephropathyrenal prognosisunsupervised clustering

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

550
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

33.7K

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
24
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
33