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Chronic Subdural Hematoma and Tranexamic Acid: A Systematic Review
Beatriz Rodrigues Messias1, João Paulo Macedo Borges, Andre FELiX GENTiL
1Albert Einstein Instituto Israelita de Ensino e Pesquisa, São Paulo ? São Paulo (SP), Brazil.
Tranexamic acid (TXA) is safe and effective as an adjunct to surgery for chronic subdural hematoma (cSDH). More research is needed to confirm its efficacy as a primary treatment for cSDH.
Area of Science:
- Neurosurgery
- Pharmacology
Background:
- Chronic subdural hematoma (cSDH) presents a significant clinical challenge.
- Evaluating treatment options for cSDH is crucial for patient outcomes.
Approach:
- Systematic review adhering to PRISMA guidelines.
- Comprehensive literature search across five databases up to February 2024.
- Inclusion of RCTs, cohort studies, systematic reviews, and case series (>5 patients).
Key Points:
- Analyzed 10 studies involving 912 patients with cSDH treated with tranexamic acid (TXA).
- Seven studies explored TXA as an adjunct to surgical intervention.
- Three studies investigated TXA as a primary therapeutic agent.
Conclusions:
- Tranexamic acid (TXA) demonstrates safety and efficacy when used as an adjunct to surgical management for cSDH.
- Further investigation is warranted to establish the role of TXA in primary treatment protocols for cSDH.
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