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RobustEMD: Domain robust matching for cross-domain few-shot medical image segmentation
Yazhou Zhu1, Minxian Li1, Qiaolin Ye2
1School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Artificial Intelligence in Medicine
|June 27, 2025
Summary
This study introduces a new method for cross-domain few-shot medical image segmentation (CD-FSMIS), improving model generalization across different data sources. The RobustEMD mechanism enhances segmentation accuracy in diverse clinical settings.
Area of Science:
- Medical image analysis
- Computer vision
- Machine learning
Background:
- Few-shot medical image segmentation (FSMIS) models typically perform poorly when data comes from different domains (e.g., varying modalities, institutions, or equipment).
- Clinical applications require models that can generalize across these diverse medical imaging data domains.
Purpose of the Study:
- To introduce Cross-domain Few-shot Medical Image Segmentation (CD-FSMIS) and propose a novel RobustEMD matching mechanism.
- To enhance the cross-domain generalization capability of medical image segmentation models.
Main Methods:
- Developed a RobustEMD matching mechanism utilizing Earth Mover's Distance (EMD).
- Incorporated a channel-wise feature decomposition strategy to divide features into local nodes.
- Implemented a texture structure aware weights generation method using Sobel-based gradients to restrain domain-specific features.
- Employed a boundary-aware Hausdorff distance for transportation cost calculation.
Main Results:
- The proposed RobustEMD mechanism significantly improved performance in cross-modal, cross-sequence, and cross-institution segmentation scenarios.
- Ablation studies confirmed the contribution of each component of the RobustEMD mechanism to enhanced performance.
- The model demonstrated strong generalization capabilities in heterogeneous medical imaging environments.
Conclusions:
- The RobustEMD mechanism effectively addresses the challenge of domain shift in few-shot medical image segmentation.
- This approach offers a promising solution for real-world clinical applications requiring robust segmentation across diverse data sources.
- The method shows significant potential for advancing medical image analysis in heterogeneous environments.

