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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

216
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
216

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Related Experiment Video

Updated: Sep 17, 2025

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
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Accelerated deep intermittent theta-burst stimulation for obsessive-compulsive disorder: A double-blind, randomized,

Gizem Kavas Akyol1, Bengü Yucens1, Selim Tumkaya2

  • 1Pamukkale University, Medicine Faculty, Department of Psychiatry, Turkey.

Journal of Psychiatric Research
|June 27, 2025
PubMed
Summary

This study explored an accelerated deep intermittent theta burst stimulation (d-iTBS) protocol for obsessive-compulsive disorder (OCD). While initial results showed promise, therapeutic effects for OCD symptoms may emerge weeks after treatment completion.

Keywords:
Age at onsetObsessive-compulsive disorderPlacebo effectTheta-burst stimulationTranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Trials

Background:

  • The standard FDA-approved protocol for Obsessive-Compulsive Disorder (OCD) involves six weeks of 20 Hz deep transcranial magnetic stimulation (dTMS) targeting the medial prefrontal cortex (mPFC).
  • The efficacy of accelerated deep intermittent theta burst stimulation (d-iTBS) for OCD, targeting the same region, has not been established through randomized controlled trials.

Purpose of the Study:

  • To investigate the efficacy of a modified, shorter-duration d-iTBS protocol for treating OCD.
  • To evaluate changes in obsessive-compulsive symptoms (OCS), as well as depressive and anxiety symptoms, following the accelerated d-iTBS intervention.

Main Methods:

  • A randomized controlled trial was conducted using a two-week accelerated d-iTBS protocol (50 sessions total) targeting the mPFC.
  • Primary outcome measures included the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Dimensional Obsessive-Compulsive Scale.
  • Changes in clinical scores were analyzed using repeated measures ANOVA.

Main Results:

  • A statistically significant Group × Time interaction was observed for the reduction in total OCS, indicating a difference between active and placebo groups.
  • No significant effects were found for obsessions and compulsions analyzed separately or across specific OCS dimensions.
  • Reductions in depressive and anxiety symptoms did not reach statistical significance.
  • A trend toward significance (p = 0.051) was noted for score reduction between treatment endpoint and two-week follow-up.

Conclusions:

  • Accelerated d-iTBS targeting the mPFC shows potential for reducing OCD symptoms.
  • Therapeutic effects of this accelerated d-iTBS protocol may manifest more clearly several weeks post-treatment.
  • The trial is registered on ClinicalTrials.gov (NCT06177470).