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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
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Choroid plexus enlargement and Kappa light chains index reflect distinct pathophysiological processes in Multiple
Natalia Shor1, Vito Ag Ricigliano2, Gaspard Martet3
1Sorbonne University, Paris Brain Institute - ICM, Paris, France; Departement of Neuroradiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière hospital, Paris, France.
Multiple Sclerosis and Related Disorders
|June 27, 2025
Summary
No correlation exists between choroid plexus volume and the Kappa free light chain index in multiple sclerosis (MS) patients. These biomarkers likely indicate separate disease processes in MS.
Area of Science:
- Neuroimmunology
- Biomarker Discovery
- Neurodegenerative Diseases
Background:
- Multiple sclerosis (MS) is a complex neuroinflammatory and neurodegenerative disorder.
- Choroid plexus (CP) volume and Kappa free light chain index (K-index) are emerging biomarkers in MS.
- The relationship between CP volume and K-index in MS is not well understood.
Purpose of the Study:
- To investigate the association between CP volume and K-index in people with MS (PwMS).
- To explore correlations between CP volume or K-index and disease duration, CSF cellularity, and brain volumetric parameters.
Main Methods:
- Retrospective, multicentric study of 82 adult PwMS.
- 3DT1 gradient echo MRI for CP volume measurement (normalized by intracranial volume).
- K-index calculated from CSF and serum free light chains; statistical analysis using partial correlations adjusted for covariates.
Main Results:
- No significant correlation found between CP volume and K-index (r = -0.016, p = 0.89).
- Larger CP volume correlated with increased ventricular volume, older age, and longer disease duration.
- K-index was inversely associated with age; not linked to structural brain alterations.
Conclusions:
- CP volume and K-index show no correlation in PwMS.
- These biomarkers likely reflect distinct pathophysiological mechanisms in multiple sclerosis.
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