A Survey Study of Roadblocks in Translational Science

Area of Science:

• Clinical and translational science
• Research barriers and roadblocks

Background:

• Clinical and translational science requires overcoming significant roadblocks to advance research.
• Understanding these barriers is crucial for improving research efficiency.

Purpose of the Study:

• To identify and prioritize the leading barriers and roadblocks encountered in clinical and translational research.
• To gather insights from researchers and staff at two academic institutions.

Main Methods:

• A 20-item questionnaire was developed based on literature review and stakeholder input.
• Surveys were distributed to faculty and staff with active research protocols at Baylor College of Medicine and the University of Houston.
• 227 respondents from various research disciplines (basic, translational, clinical) completed the survey.

Main Results:

• Top roadblocks identified: lack of trained research coordinators, poor understanding of available resources, complex regulatory environment, fragmented administrative/fiscal infrastructure, and inadequate pilot project funding.
• Other cited barriers include limited access to medical records and insufficient biostatistical support.
• Respondents prioritized these issues based on their impact on research.

Conclusions:

• Key operational and systemic barriers hinder clinical and translational research progress.
• Targeted innovations addressing these identified roadblocks can significantly accelerate the pace of research translation.
• Addressing infrastructure, funding, and regulatory challenges is essential for scientific advancement.