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  11. 3d-printed Hydrogel Patch For Controlled Topical Release: Gelatin/tannic Acid Formulation Meets Additive Manufacturing

3D-printed hydrogel patch for controlled topical release: Gelatin/tannic acid formulation meets additive manufacturing

Angélica Graça1, Valeria Tonioli2, Ana M Martins1

  • 1Research Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|June 27, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Personalized 3D-printed hydrogel patches offer a novel solution for mask-related skin issues like rosacea and maskne. These customizable patches deliver active ingredients effectively, showing potential for improved dermatological treatment.

Area of Science:

  • Biomaterials Science
  • Dermatology
  • 3D Printing Technology

Background:

  • Prolonged mask use can lead to skin conditions such as rosacea and acne ('maskne'), exacerbated by ill-fitting commercial dressings.
  • Healthcare workers are particularly susceptible to these mask-induced dermatological issues.
  • There is a need for personalized and effective treatments for mask-related skin problems.

Purpose of the Study:

  • To explore the development of customizable 3D-printed hydrogel patches for treating mask-induced skin conditions.
  • To investigate the use of gelatin/tannic acid hydrogels incorporating metronidazole (for rosacea) or salicylic acid (for maskne).
  • To optimize 3D printing parameters and assess patch performance for controlled drug delivery.

Main Methods:

  • Utilized a Quality by Design approach with Design of Experiments to determine optimal 3D printing conditions for gelatin/tannic acid hydrogels.
Keywords:
3D PrintingControlled releaseHydrogelPersonalized therapies

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  • Characterized rheological properties (gelation temperature, viscosity, gelation time) and mechanical properties (tensile strength) of the hydrogel patches.
  • Fabricated three patch designs (occlusive, grid, triangular infill) and evaluated in vitro drug release and permeation profiles for metronidazole and salicylic acid.

    • Main Results:

    • Optimal printing conditions were identified for both metronidazole and salicylic acid formulations, varying in temperature and pressure.
    • Infill patterns significantly influenced mechanical strength and drug release rates, with grid patterns demonstrating superior properties.
    • In vitro permeation studies showed salicylic acid penetrated the skin barrier, indicating potential for therapeutic efficacy despite low overall drug retention.

    Conclusions:

    • Customizable 3D-printed hydrogel patches represent a promising personalized approach for managing mask-related skin conditions.
    • The study demonstrates the feasibility of tailoring patch design and formulation for targeted delivery of active ingredients like metronidazole and salicylic acid.
    • Further research into optimizing drug retention and long-term efficacy is warranted for clinical application.
    Skin lesions
    Topical delivery systems