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Terpenoids from Aglaia edulis and their lung epithelial cells protective activity
Ling Li1, Qianqian Yin1, Yanping Zhang1
1School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
None:
A significant protective effect on lung epithelial cells was observed with the terpenoids of Aglaia edulis twigs and leaves. Lung epithelial cells protective activity guided phytochemical research afforded nineteen triterpenoids (1-19), six diterpenoids (20-25) and four sesquiterpenes (26-29), including four unreported compounds (1, 16, 20 and 22), from A. edulis. All structures were clarified by HR-ESI-MS, NMR and ECD spectra. The lung epithelial protective effect of these compounds was assessed using NNK-induced MLE-12 cells. Biological assay indicated that compounds 1-2, 4-6, 8, 10, 12-15 could reverse the damage induced by NNK in MLE-12 cells.
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