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Association of MMP-11 Genotypes With Colorectal Cancer in Taiwan
Tao-Wei Ke1,2, Ming-Hsien Wu3,4,5, Ying-Jing Chen6
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Background/Aim:
Matrix metalloproteinase-11 (MMP-11) is a member of the MMP enzyme family, known for its critical function in extracellular matrix turnover and tissue restructuring. This study aimed to investigate the potential associations between four MMP-11 single-nucleotide polymorphisms (SNPs)-rs738791, rs2267029, rs738792, and rs28382575-and colorectal cancer (CRC) susceptibility in a Taiwanese cohort.
Materials And Methods:
A total of 362 CRC patients and non-cancer controls were genotyped using the restriction fragment length polymorphism method. The distribution of genotypes and alleles was assessed, and conformity to Hardy-Weinberg equilibrium was confirmed for all examined loci (p>0.05).
Results:
No statistically significant differences were observed in the genotype frequencies of MMP-11 rs738791, rs2267029, rs738792, or rs28382575 between CRC patients and healthy controls (p for trend=0.8640, 0.6638, 0.3275, and 0.8051, respectively). Allelic analyses further revealed lack of associations with CRC risk regarding rs738791 T allele (OR=1.06, 95%CI=0.85-1.32, p=0.6550), rs2267029 A allele (OR=1.11, 95%CI=0.88-1.40, p=0.4073), rs738792 C allele (OR=1.02, 95%CI=0.81-1.29, p=0.9055), and rs28382575 C allele (OR=1.17, 95% CI=0.67-2.04, p=0.6718). Interestingly, individuals carrying the CT or TT genotypes of rs738791 were more likely to present with larger tumor sizes (≥5 cm, p=0.0298) and absence of metastasis (p=0.0218). Moreover, the AG or AA genotypes of rs2267029 were significantly associated with advanced clinical stages (III-IV, p=0.0007).
Conclusion:
Although the investigated MMP-11 polymorphisms were not associated with CRC susceptibility, the rs738791 and rs2267029 variant genotypes may serve as potential prognostic biomarkers.
Insights
Investigating matrix metalloproteinase-11 (MMP-11) single-nucleotide polymorphisms (SNPs) in Taiwanese colorectal cancer (CRC) patients revealed no link to cancer susceptibility. However, specific MMP-11 genotypes showed potential as prognostic biomarkers for tumor size and clinical stage.
Area of Science:
- Genetics
- Oncology
- Biochemistry
Background:
- Matrix metalloproteinase-11 (MMP-11) plays a role in extracellular matrix remodeling.
- Genetic variations in MMP-11 may influence cancer development and progression.
Purpose of the Study:
- To examine the association between four MMP-11 single-nucleotide polymorphisms (SNPs) and colorectal cancer (CRC) susceptibility in a Taiwanese population.
- To explore the potential of these MMP-11 SNPs as biomarkers for CRC prognosis.
Main Methods:
- Genotyping of 362 CRC patients and controls for MMP-11 SNPs (rs738791, rs2267029, rs738792, rs28382575) using restriction fragment length polymorphism.
- Statistical analysis to compare genotype and allele frequencies between cases and controls.
- Assessment of Hardy-Weinberg equilibrium for all loci.
Main Results:
- No significant association was found between the studied MMP-11 SNPs and CRC susceptibility.
- Allelic analyses did not reveal any link between the SNPs and overall CRC risk.
- The rs738791 genotypes (CT/TT) were associated with larger tumor size and absence of metastasis.
- The rs2267029 genotypes (AG/AA) were significantly linked to advanced clinical stages (III-IV).
Conclusions:
- The investigated MMP-11 polymorphisms are not associated with colorectal cancer susceptibility.
- Specific MMP-11 genotypes (rs738791 and rs2267029) may serve as potential prognostic biomarkers for CRC.
