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RXRG as a Novel Biomarker and its Correlation With Immune Infiltration in Thyroid Carcinoma
Pengzhao Song1, Tianqi Chen2, Pengfei Gu1
1Department of Thyroid Surgery, Binzhou Medical University Hospital, Binzhou, P.R. China.
Background/Aim:
Thyroid carcinoma (THCA) is the most prevalent type of endocrine cancer. Retinoid X Receptor Gamma (RXRG) encodes a member of the retinoid X receptor (RXR) family of nuclear receptors that are involved in mediating the antiproliferative effects of retinoic acid (RA). However, the role of RXRG in THCA remains unclear.
Materials And Methods:
Multiple public databases were utilized to investigate RXRG expression in THCA and its role in THCA prognosis, analyze the RXRG co-expressed genes and protein-protein interaction (PPI) networks, as well as to analyze the immune cell infiltration in THCA using enrichment analysis and the association of RXRG expression with immune cell infiltration.
Results:
The expression of RXRG is higher in THCA tissues than in normal thyroid tissues. In THCA, a reduced expression of RXRG is associated with poor prognosis. Both the pathological stage and RXRG expression are independent risk factors for the overall survival (OS) of THCA patients. RXRG is mainly associated with signaling pathways such as cytokine-cytokine receptor interaction, chemokine signaling pathway, interleukin signaling, and interleukin-18 signaling pathway, all of which may be related to immunity. Finally, it was found that the expression of RXRG is associated with the infiltration of various immune cells and may affect the prognosis of patients through changes in the immune environment.
Conclusion:
RXRG has a significant impact on the tumor microenvironment (TME) of THCA, potentially serving as a valuable biomarker for the diagnosis and treatment of this malignancy.
Insights
Retinoid X Receptor Gamma (RXRG) is upregulated in thyroid carcinoma (THCA) and associated with better patient prognosis. RXRG influences the tumor microenvironment and immune cell infiltration, suggesting its potential as a diagnostic and therapeutic biomarker.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Thyroid carcinoma (THCA) is the most common endocrine cancer.
- Retinoid X Receptor Gamma (RXRG) is part of the nuclear receptor superfamily, involved in antiproliferative effects.
- The specific role of RXRG in THCA pathogenesis and progression is not well understood.
Purpose of the Study:
- To investigate the expression patterns of RXRG in THCA.
- To determine the prognostic significance of RXRG in THCA patients.
- To explore the association of RXRG with signaling pathways and immune cell infiltration in the THCA tumor microenvironment.
Main Methods:
- Utilized multiple public databases for expression analysis.
- Performed co-expressed gene and protein-protein interaction network analysis.
- Conducted enrichment analysis for immune cell infiltration and pathway association.
Main Results:
- RXRG expression is significantly higher in THCA tissues compared to normal thyroid tissues.
- Reduced RXRG expression correlates with poorer prognosis and is an independent risk factor for overall survival in THCA patients.
- RXRG is linked to immune-related pathways (cytokine-cytokine receptor interaction, chemokine signaling) and associated with immune cell infiltration, impacting the tumor microenvironment.
Conclusions:
- RXRG plays a crucial role in modulating the tumor microenvironment of THCA.
- RXRG expression levels can serve as a potential biomarker for THCA diagnosis and treatment strategies.
