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Related Experiment Video

Updated: Sep 17, 2025

Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay
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Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay

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Studying ototoxicity in zebrafish.

Eduarda Oliveira Cunha1,2, Dora de Athayde Saul2,3, Murilo Sander de Abreu1

  • 1Graduate Program in Health Sciences, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.

Environmental Toxicology and Chemistry
|June 27, 2025
PubMed
Summary

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Zebrafish (Danio rerio) show promise as a model organism for ototoxicity research, aiding in screening xenobiotic compounds. Further research is needed to standardize evaluation methods for this important animal model.

Area of Science:

  • Toxicology
  • Auditory Science
  • Animal Models

Background:

  • Ototoxicity, damage to the auditory system from external substances (xenobiotics), is a significant health concern.
  • Animal models are crucial for advancing ototoxicity research and understanding mechanisms.
  • Zebrafish (Danio rerio) have emerged as a valuable vertebrate model in toxicological studies.

Purpose of the Study:

  • To systematically review and map the existing evidence on the utilization of zebrafish as a model organism for ototoxicity research.
  • To identify trends and gaps in the current literature regarding zebrafish in ototoxicity screening.

Main Methods:

  • An exploratory systematic literature search was conducted across Cochrane, LILACS, and PubMed databases.
  • A two-step screening process using predefined inclusion/exclusion criteria was applied to select relevant studies.
Keywords:
animal modelsauditory systemhair cellslateral linexenobiotics

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  • Outcome measures from included studies were categorized into hair cell death rate, exposure duration, and developmental stages.

    • Main Results:

    • The review identified a substantial body of literature on zebrafish for ototoxicity, including 15 non-drug xenobiotic studies and 118 drug-related studies.
    • Zebrafish demonstrated utility in screening the ototoxicity potential of various xenobiotics.
    • Key outcome measures analyzed included hair cell death, exposure time, and developmental impacts.

    Conclusions:

    • Zebrafish represent a significant and increasingly utilized model for screening the ototoxicity of xenobiotics.
    • There is a clear need for novel research to establish standardized protocols and optimal evaluation outcomes for zebrafish ototoxicity studies.
    • Further standardization will enhance the reliability and comparability of results in ototoxicity research using zebrafish.